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Symbol
Name
ID

Fbxw7
F-box and WD-40 domain protein 7
MGI:1354695

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Neutropenia	Recurrent pneumonia
Disease(s) Associated with FBXW7	Neutropenia	Recurrent pneumonia
developmental delay, hypotonia, and impaired language

Mouse Phenotypes		immune system phenotype	increased T cell apoptosis	enlarged thymus	thymus hypoplasia	abnormal T cell differentiation	decreased double-negative T cell number	increased double-positive T cell number	arrested T cell differentiation	decreased single-positive T cell number	abnormal T cell activation
Availability	Mouse Genotype	immune system phenotype	increased T cell apoptosis	enlarged thymus	thymus hypoplasia	abnormal T cell differentiation	decreased double-negative T cell number	increased double-positive T cell number	arrested T cell differentiation	decreased single-positive T cell number	abnormal T cell activation
	Fbxw7^tm1Iaai/Fbxw7^tm1Iaai Tg(Lck-cre)1Cwi/0 (conditional)	*
	Fbxw7^tm1Iaai/Fbxw7^tm1Iaai Tg(Mx1-cre)1Cgn/0 (conditional)
	Fbxw7^tm1Kei/Fbxw7^tm1Kei Tg(Lck-cre)1Cwi/? (conditional)
	Fbxw7^tm1Kei/Fbxw7^tm1Kei Tg(Cd4-cre)1Cwi/? (conditional)
	Fbxw7^tm2Iaai/Fbxw7⁺ Tg(Mx1-cre)1Cgn/0 (conditional)	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23